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However, increased cGMP concentration has also been observed to coincide with (NO-mediated) increases in mitochondrial biogenesis ( Alternatively, NO also stimulates mitochondrial biogenesis via the activation of 5-AMP-activated protein kinase (AMPK) ( Role of NO in mitochondrial function Nitric oxide regulates mitochondrial function both indirectly by modulating systemic responses and directly by interacting with the electron transport chain complexes

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